Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 사홍기 | - |
dc.date.accessioned | 2016-10-14T01:10:50Z | - |
dc.date.available | 2016-10-14T01:10:50Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.other | OAK-19393 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232383 | - |
dc.description.abstract | The purpose of this research was to produce porous sponge-like PLGA microspheres through a simple emulsion technique using a non-halogenated organic solvent and methylamine. In order to achieve this objective, a dispersed phase consisting of PLGA and methyl propionate was emulsified in an aqueous polyvinyl alcohol solution to produce an oil-in-water emulsion. When methylamine was added to the aqueous phase, it partitioned to the oil phase and reacted with methyl propionate to produce methanol and N-methyl propionamide. These water-soluble decomposition products acted as anti-solvents against PLGA. As they leached to the aqueous phase, oil droplets effectively hardened to sponge-like microspheres. This technique, utilizing a chemical reaction between the dispersed solvent and methylamine, has shown excellence compared to the existing water-in-oil-in-water emulsion techniques that require the help of porogens. For example, even without using porogens and high-shear/high-energy mixing devices, our simple technology made it possible to produce very porous microspheres with a sponge-like skeleton. Also, rather than using halogenated methylene chloride, which has been commonly used to produce microspheres, this new technique used methyl propionate, a non-halogenated and safer alternative. Furthermore, it enabled us to adjust the amount of residual methyl propionate in the microspheres below 0.5%, meeting the standard of residual organic solvents in microspheres set by regulatory authorities. The innovative technology reported in this study would make a large contribution to producing porous microspheres with the use of various hydrophobic polymers. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Methylamine acts as excellent chemical trigger to Harden emulsion droplets into spongy PLGA microspheres | - |
dc.type | Article | - |
dc.relation.issue | 88 | - |
dc.relation.volume | 6 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 85275 | - |
dc.relation.lastpage | 85284 | - |
dc.relation.journaltitle | RSC ADVANCES | - |
dc.identifier.doi | 10.1039/c6ra17576g | - |
dc.identifier.wosid | WOS:000384139000083 | - |
dc.identifier.scopusid | 2-s2.0-84987661034 | - |
dc.author.google | Kim, Yuyoung | - |
dc.author.google | Kim, Hansol | - |
dc.author.google | Sah, Hongkee | - |
dc.contributor.scopusid | 사홍기(56127728100) | - |
dc.date.modifydate | 20190901081003 | - |