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Anti-adipogenic and anti- diabetic effects of cis-3 ',4 '-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

Title
Anti-adipogenic and anti- diabetic effects of cis-3 ',4 '-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro
Authors
Choi, Ra-YeongNam, Sang-JipHam, Ju RiLee, Hae-InYee, Sung-TaeKang, Kyung-YunSeo, Kwon-IlLee, Ju-HyeKim, Myung-JooLee, Mi-Kyung
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2016
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN
0960-894XJCR Link1464-3405JCR Link
Citation
vol. 26, no. 19, pp. 4655 - 4660
Keywords
AdipocytesAdipogenesisAnti-diabetesAnti-obesityPeucedanum japonicum Thunb leaves
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (3' and 5' mu M) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBP alpha, PPAR gamma and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential alpha-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2016.08.056
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자연과학대학 > 화학·나노과학전공 > Journal papers
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