DSpace at EWHA: Anti-adipogenic and anti- diabetic effects of cis-3 ',4 '-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

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DSpace at EWHA자연과학대학 화학·나노과학전공 Journal papers

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DC Field	Value	Language
dc.contributor.author	남상집	*
dc.date.accessioned	2016-09-21T01:09:13Z	-
dc.date.available	2016-09-21T01:09:13Z	-
dc.date.issued	2016	*
dc.identifier.issn	0960-894X	*
dc.identifier.issn	1464-3405	*
dc.identifier.other	OAK-19307	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/232236	-
dc.description.abstract	Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (3' and 5' mu M) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBP alpha, PPAR gamma and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential alpha-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity. (C) 2016 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD	*
dc.subject	Adipocytes	*
dc.subject	Adipogenesis	*
dc.subject	Anti-diabetes	*
dc.subject	Anti-obesity	*
dc.subject	Peucedanum japonicum Thunb leaves	*
dc.title	Anti-adipogenic and anti- diabetic effects of cis-3 ',4 '-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro	*
dc.type	Article	*
dc.relation.issue	19	*
dc.relation.volume	26	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	4655	*
dc.relation.lastpage	4660	*
dc.relation.journaltitle	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS	*
dc.identifier.doi	10.1016/j.bmcl.2016.08.056	*
dc.identifier.wosid	WOS:000383359400019	*
dc.identifier.scopusid	2-s2.0-84985995782	*
dc.author.google	Choi, Ra-Yeong	*
dc.author.google	Nam, Sang-Jip	*
dc.author.google	Ham, Ju Ri	*
dc.author.google	Lee, Hae-In	*
dc.author.google	Yee, Sung-Tae	*
dc.author.google	Kang, Kyung-Yun	*
dc.author.google	Seo, Kwon-Il	*
dc.author.google	Lee, Ju-Hye	*
dc.author.google	Kim, Myung-Joo	*
dc.author.google	Lee, Mi-Kyung	*
dc.contributor.scopusid	남상집(57208839798)	*
dc.date.modifydate	20240220120010	*