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Reverse thermogelling biodegradable polymer aqueous solutions

Title
Reverse thermogelling biodegradable polymer aqueous solutions
Authors
Joo M.K.Park M.H.Choi B.G.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2009
Journal Title
Journal of Materials Chemistry
ISSN
0959-9428JCR Link
Citation
vol. 19, no. 33, pp. 5891 - 5905
Indexed
SCOPUS WOS scopus
Abstract
A reverse thermogelling polymer aqueous solution is a free-flowing sol at a low temperature and becomes a semisolid gel as the temperature increases. It is expected to be a very promising biomaterial as a minimally invasive injectable system for drug delivery and tissue engineering applications. The principles of materials design are (1) balancing the hydrophobicity and hydrophilicty of a polymer, (2) controlling the topology of a polymer, (3) matching the degradation kinetics of a polymer with a specific biomedical application, and (4) controlling the biocompatibility of the material with a drug as well as a host. This article covers recent progress of reverse theromogelling biodegradable polymers based on aliphatic polyesters, polyphosphazenes, poloxamer derivatives, polysaccharides, polypeptides, poly(propylene phosphate)s, polyorthoesters, polycarbonates, polycyanoacrylates, and poly(N-(2-hydroxyethyl) methacrylamide-lactate)s. The material characteristics, driving forces or mechanism for sol-gel transition, and their biomedical applications are summarized. In addition, the authors' perspectives on future reverse theromogelling materials design are suggested. © The Royal Society of Chemistry 2009.
DOI
10.1039/b902208b
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자연과학대학 > 화학·나노과학전공 > Journal papers
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