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Reverse thermogelling biodegradable polymer aqueous solutions
- Reverse thermogelling biodegradable polymer aqueous solutions
- Joo M.K.; Park M.H.; Choi B.G.; Jeong B.
- Ewha Authors
- SCOPUS Author ID
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- Journal Title
- Journal of Materials Chemistry
- vol. 19, no. 33, pp. 5891 - 5905
- A reverse thermogelling polymer aqueous solution is a free-flowing sol at a low temperature and becomes a semisolid gel as the temperature increases. It is expected to be a very promising biomaterial as a minimally invasive injectable system for drug delivery and tissue engineering applications. The principles of materials design are (1) balancing the hydrophobicity and hydrophilicty of a polymer, (2) controlling the topology of a polymer, (3) matching the degradation kinetics of a polymer with a specific biomedical application, and (4) controlling the biocompatibility of the material with a drug as well as a host. This article covers recent progress of reverse theromogelling biodegradable polymers based on aliphatic polyesters, polyphosphazenes, poloxamer derivatives, polysaccharides, polypeptides, poly(propylene phosphate)s, polyorthoesters, polycarbonates, polycyanoacrylates, and poly(N-(2-hydroxyethyl) methacrylamide-lactate)s. The material characteristics, driving forces or mechanism for sol-gel transition, and their biomedical applications are summarized. In addition, the authors' perspectives on future reverse theromogelling materials design are suggested. © The Royal Society of Chemistry 2009.
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