View : 16 Download: 0

Temperature-sensitive biodegradable poly(ethylene glycol)

Title
Temperature-sensitive biodegradable poly(ethylene glycol)
Authors
Lee J.Joo M.K.Kim J.Park J.S.Yoon M.-Y.Jeong B.
Ewha Authors
정병문김진흥
SCOPUS Author ID
정병문scopus; 김진흥scopus
Issue Date
2009
Journal Title
Journal of Biomaterials Science, Polymer Edition
ISSN
0920-5063JCR Link
Citation
vol. 20, no. 41463, pp. 957 - 965
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We report here that the incorporation of several disulfide bonds along poly(ethylene glycol) (PEG) gives temperature sensitivity, as well as biodegradability to PEG. To synthesize a PEG with temperature sensitivity in a physiologically important range (20-40°C), PEGs with molecular masses of 400 and 600 Da were randomly coupled by disulfide bonds. As the mol ratio of PEG (400 Da) disulfide to PEG (600 Da) disulfide increased from 40:60 to 60:40, the cloud point of the polymer aqueous solution decreased from 35°C to 27°C. The disulfide bonds between PEGs were degraded in the presence of a thiol-containing biomolecule of glutathione in a thiol-concentration-dependent manner. © 2009 Koninklijke Brill NV, Leiden.
DOI
10.1163/156856209X444367
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE