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Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis

Title
Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis
Authors
Shin, JihyeKim, You JinKwon, OranKim, Nack-InCho, Yunhi
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2016
Journal Title
NUTRITION RESEARCH AND PRACTICE
ISSN
1976-1457JCR Link2005-6168JCR Link
Citation
vol. 10, no. 4, pp. 398 - 403
Keywords
Atopic dermatitisvitamin Cceramideclinical severity
Publisher
KOREAN NUTRITION SOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
BACKGROUND/OBJECTIVES: Atopic dermatitis (AD), a chronic inflammatory skin disease, is accompanied by disruption of the epidermal lipid barrier, of which ceramide (Cer) is the major component. Recently it was reported that vitamin C is essential for de novo synthesis of Cer in the epidermis and that the level of vitamin C in plasma is decreased in AD. The objective of this study was to determine the associations among clinical severity, vitamin C in either plasma or epidermis, and Cer in the epidermis of patients with AD. SUBJECTS/METHODS: A total of 17 patients (11 male and 6 female) aged 20-42 years were enrolled. The clinical severity of AD was assessed according to the SCORAD (SCORing Atopic Dermatitis) system. Levels of vitamin C were determined in plasma and biopsies of lesional epidermis. Levels of epidermal lipids, including Cer, were determined from tape-stripped lesional epidermis. RESULTS: The clinical severity of patients ranged between 0.1 and 45 (mild to severe AD) based on the SCORAD system. As the SCORAD score increased, the level of vitamin C in the plasma, but not in the epidermis, decreased, and levels of total Cer and Cer2, the major Cer species in the epidermis, also decreased. There was also a positive association between level of vitamin C in the plasma and level of total Cer in the epidermis. However, levels of epidermal total lipids including triglyceride, cholesterol, and free fatty acid (FFA) were not associated with either SCORAD score or level of vitamin C in the plasma of all subjects. CONCLUSIONS: As the clinical severity of AD increased, level of vitamin C in the plasma and level of epidermal Cer decreased, and there was a positive association between these two parameters, implying associations among plasma vitamin C, epidermal Cer, and the clinical severity of AD.
DOI
10.4162/nrp.2016.10.4.398
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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