Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2016-08-29T12:08:51Z | - |
dc.date.available | 2016-08-29T12:08:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1475-2891 | * |
dc.identifier.other | OAK-18695 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231585 | - |
dc.description.abstract | Background: Previous animal studies suggested that Chlorella, a unicellular green alga, has a preventive role in maintaining serum cholesterol levels against excess dietary cholesterol intake. This study aimed to conduct a pioneering investigation to clarify this issue in healthy subjects by adopting a dietary cholesterol challenge, which has not been used previously in similar studies of Chlorella in hypercholesterolemia. Methods: In this double blind, randomized, placebo-controlled study, 34 participants ingested 510 mg of dietary cholesterol from three eggs concomitantly with a usual dose of Chlorella (5 g/d) or a matched placebo for 4 weeks. Results: The dietary cholesterol challenge induced consistently higher concentrations of serum total cholesterol (TC, P < 0.001), LDL-C (P = 0.004), and HDL-C (P = 0.010) compared with baseline values, suggesting that the challenge was reliable. Thus, we observed a preventive action of Chlorella in maintaining serum TC versus placebo levels (3.5 % versus 9.8 %, respectively; P = 0.037) and LDL-C versus placebo levels (1.7 % versus 14.3 %, respectively; P = 0.012) against excessive dietary cholesterol intake and in augmenting HDL-C versus placebo levels (8.3 % versus 3.8 %, respectively). Furthermore, serum α-carotene showed the best separation between the placebo and Chlorella groups (R2X and R2Y > 0.5; Q2 > 0.4). Conclusion: The results suggest that a fully replicated dietary cholesterol challenge may be useful in assessing the effectiveness of dietary supplements in maintaining the serum lipid profiles of adults whose habitual diets are high in cholesterol. © 2016 Kim et al. | * |
dc.language | English | * |
dc.publisher | BioMed Central Ltd. | * |
dc.subject | Carotenoids | * |
dc.subject | Chlorella | * |
dc.subject | Dietary cholesterol challenge | * |
dc.subject | Healthy adult | * |
dc.title | A dietary cholesterol challenge study to assess Chlorella supplementation in maintaining healthy lipid levels in adults: A double-blinded, randomized, placebo-controlled study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nutrition Journal | * |
dc.identifier.doi | 10.1186/s12937-016-0174-9 | * |
dc.identifier.wosid | WOS:000376008400001 | * |
dc.identifier.scopusid | 2-s2.0-84971261025 | * |
dc.author.google | Kim S. | * |
dc.author.google | Kim J. | * |
dc.author.google | Lim Y. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Kwon O. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123125010 | * |