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Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

Title
Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts
Authors
Lee Y.J.Lee E.Han A.-R.Song J.-I.Kwon Y.Seo E.-K.
Ewha Authors
송준임서은경권영주한아름
SCOPUS Author ID
송준임scopus; 서은경scopus; 권영주scopus; 한아름scopusscopus
Issue Date
2012
Journal Title
Natural Product Sciences
ISSN
1226-3907JCR Link
Citation
vol. 18, no. 2, pp. 102 - 105
Indexed
SCOPUS; KCI scopus
Abstract
Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.
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자연과학대학 > 생명과학전공 > Journal papers
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