Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송준임 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 권영주 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-29T12:08:24Z | - |
dc.date.available | 2016-08-29T12:08:24Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1226-3907 | * |
dc.identifier.other | OAK-18221 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231316 | - |
dc.description.abstract | Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study. | * |
dc.language | English | * |
dc.title | Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 102 | * |
dc.relation.lastpage | 105 | * |
dc.relation.journaltitle | Natural Product Sciences | * |
dc.identifier.scopusid | 2-s2.0-84865216680 | * |
dc.author.google | Lee Y.J. | * |
dc.author.google | Lee E. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Song J.-I. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Seo E.-K. | * |
dc.contributor.scopusid | 송준임(55500861300) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240422124907 | * |