View : 34 Download: 0

Comparison of protective effects of young and ripened persimmon extracts against inflammatory stress induced by deoxycholic acid in small intestinal cells

Title
Comparison of protective effects of young and ripened persimmon extracts against inflammatory stress induced by deoxycholic acid in small intestinal cells
Authors
KimL.KwonO.J.Y.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2015
Journal Title
Journal of the Korean Society of Food Science and Nutrition
ISSN
1226-3311JCR Link
Citation
vol. 44, no. 10, pp. 1583 - 1587
Keywords
Caco-2Deoxycholic acidInflammationTanninYoung persimmon
Publisher
Korean Society of Food Science and Nutrition
Indexed
SCOPUS; KCI scopus
Abstract
Bile acids are endogenous metabolites that aid in the digestion and absorption of ingested fat and fat-soluble vitamins. However, high concentrations of deoxycholic acid (DCA) in the colon are associated with high incidence of colorectal cancer. In the present study, the binding of persimmon extracts to DCA in order to decrease inflammatory stress induced by DCA in a small intestinal epithelial cell line, Caco-2, was investigated. Young and ripened persimmons were extracted with distilled water (DW), ethanol, and acidic ethanol. Further, DW extract residue was re-extracted with acidic ethanol. Of the obtained extracts, acidic ethanol extract of young persimmon showed the highest bile-acid binding capacity. Moreover, acidic ethanol extract of young persimmon significantly inhibited nitric oxide production in Caco-2 cells stimulated with DCA and prevented significant reduction of trans-epithelial electric resistance. Based on these results, acidic ethanol extract of young persimmon can be used as a functional ingredient to enhance gastrointestinal health. © 2015, Korean Society of Food Science and Nutrition. All rights reserved.
DOI
10.3746/jkfn.2015.44.10.1583
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE