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Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Title
Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
Authors
LiuT.ZhouY.KoK.S.YangH.
Ewha Authors
고광석
SCOPUS Author ID
고광석scopus
Issue Date
2015
Journal Title
Mediators of Inflammation
ISSN
0962-9351JCR Link
Citation
vol. 2015
Publisher
Hindawi Publishing Corporation
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro-and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed. © 2015 Ting Liu et al.
DOI
10.1155/2015/276850
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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