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Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
- Title
- Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
- Authors
- Liu; T.; Zhou; Y.; Ko; K.S.; Yang; H.
- Ewha Authors
- 고광석
- SCOPUS Author ID
- 고광석
- Issue Date
- 2015
- Journal Title
- Mediators of Inflammation
- ISSN
- 0962-9351
- Citation
- Mediators of Inflammation vol. 2015
- Publisher
- Hindawi Publishing Corporation
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro-and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed. © 2015 Ting Liu et al.
- DOI
- 10.1155/2015/276850
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
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Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases.pdf(1.37 MB)
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