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β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells

Title
β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells
Authors
Ko J.Bao C.Park H.-C.Kim M.Choi H.-K.Kim Y.-S.Lee H.J.
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2015
Journal Title
Bioscience, Biotechnology and Biochemistry
ISSN
9168-8451JCR Link
Citation
vol. 79, no. 6, pp. 1011 - 1017
Keywords
Breast cancerCyclin D1Estrogen receptorUbiquitinationβ-thujaplicin
Publisher
Japan Society for Bioscience Biotechnology and Agrochemistry
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
β-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigene-sis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiqui-tination, which led to cell growth inhibition. These results suggest that β-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
DOI
10.1080/09168451.2015.1008978
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엘텍공과대학 > 식품공학전공 > Journal papers
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