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β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells
- β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells
- Ko J.; Bao C.; Park H.-C.; Kim M.; Choi H.-K.; Kim Y.-S.; Lee H.J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Bioscience, Biotechnology and Biochemistry
- vol. 79, no. 6, pp. 1011 - 1017
- Breast cancer; Cyclin D1; Estrogen receptor; Ubiquitination; β-thujaplicin
- Japan Society for Bioscience Biotechnology and Agrochemistry
- SCI; SCIE; SCOPUS
- β-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigene-sis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiqui-tination, which led to cell growth inhibition. These results suggest that β-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
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