Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영석 | * |
dc.date.accessioned | 2016-08-29T12:08:14Z | - |
dc.date.available | 2016-08-29T12:08:14Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 9168-8451 | * |
dc.identifier.other | OAK-15159 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230648 | - |
dc.description.abstract | β-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigene-sis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiqui-tination, which led to cell growth inhibition. These results suggest that β-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry. | * |
dc.language | English | * |
dc.publisher | Japan Society for Bioscience Biotechnology and Agrochemistry | * |
dc.subject | Breast cancer | * |
dc.subject | Cyclin D1 | * |
dc.subject | Estrogen receptor | * |
dc.subject | Ubiquitination | * |
dc.subject | β-thujaplicin | * |
dc.title | β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 79 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1011 | * |
dc.relation.lastpage | 1017 | * |
dc.relation.journaltitle | Bioscience, Biotechnology and Biochemistry | * |
dc.identifier.doi | 10.1080/09168451.2015.1008978 | * |
dc.identifier.wosid | WOS:000356239400021 | * |
dc.identifier.scopusid | 2-s2.0-84940093475 | * |
dc.author.google | Ko J. | * |
dc.author.google | Bao C. | * |
dc.author.google | Park H.-C. | * |
dc.author.google | Kim M. | * |
dc.author.google | Choi H.-K. | * |
dc.author.google | Kim Y.-S. | * |
dc.author.google | Lee H.J. | * |
dc.contributor.scopusid | 김영석(56155360400;57193073735) | * |
dc.date.modifydate | 20240322114732 | * |