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Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Title
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
Authors
Zigdon H.Kogot-Levin A.Park J.-W.Goldschmidt R.Kelly S.Merrill Jr. A.H.Scherz A.Pewzner-Jung Y.Saada A.Futerman A.H.
Ewha Authors
박준우
SCOPUS Author ID
박준우scopusscopus
Issue Date
2013
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 288, no. 7, pp. 4947 - 4956
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.M112.402719
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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