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Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2
- Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2
- Jang D.S.; Cuendet M.; Su B.-N.; Totura S.; Riswan S.; Fong H.H.S.; Pezzuto J.M.; Kinghorn A.D.
- Ewha Authors
- Issue Date
- Journal Title
- Planta Medica
- vol. 70, no. 10, pp. 893 - 896
- SCI; SCIE; SCOPUS
- A new dibenzylbutyrolactone lignan, (2R,3R)-5′-methoxyguayarol (1), was isolated from an EtOAc-soluble extract of the seeds of Hernandia ovigera using an in vitro activity-guided fractionation procedure based on the inhibition of cyclooxygenase-2. Also obtained were three known fatty acid derivatives, (S)-coriolic acid, (±)-12,13-epoxyoleic acid, and (±)-glycerol 1-monolinolate, and seven known lignans, epiashantin, dehydrodesoxypodophyllotoxin, dehydropodophyllotoxin, (-)-hernolactone, (-)-pinoresinol, (-)-syringaresinol, and (-)-yatein. The structure, including absolute stereochemistry, of compound 1 was determined using spectroscopic methods. All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, with (S)-coriolic acid and (±)-glycerol 1-monolinolate shown to have selective inhibitory activity with cyclooxygenase-2.
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