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Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2

Title
Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2
Authors
Jang D.S.Cuendet M.Su B.-N.Totura S.Riswan S.Fong H.H.S.Pezzuto J.M.Kinghorn A.D.
Ewha Authors
장대식
Issue Date
2004
Journal Title
Planta Medica
ISSN
0032-0943JCR Link
Citation
vol. 70, no. 10, pp. 893 - 896
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
A new dibenzylbutyrolactone lignan, (2R,3R)-5′-methoxyguayarol (1), was isolated from an EtOAc-soluble extract of the seeds of Hernandia ovigera using an in vitro activity-guided fractionation procedure based on the inhibition of cyclooxygenase-2. Also obtained were three known fatty acid derivatives, (S)-coriolic acid, (±)-12,13-epoxyoleic acid, and (±)-glycerol 1-monolinolate, and seven known lignans, epiashantin, dehydrodesoxypodophyllotoxin, dehydropodophyllotoxin, (-)-hernolactone, (-)-pinoresinol, (-)-syringaresinol, and (-)-yatein. The structure, including absolute stereochemistry, of compound 1 was determined using spectroscopic methods. All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, with (S)-coriolic acid and (±)-glycerol 1-monolinolate shown to have selective inhibitory activity with cyclooxygenase-2.
DOI
10.1055/s-2004-832612
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자연과학대학 > 생명과학전공 > Journal papers
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