Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장대식 | - |
dc.date.accessioned | 2016-08-28T11:08:11Z | - |
dc.date.available | 2016-08-28T11:08:11Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.other | OAK-13370 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229377 | - |
dc.description.abstract | A new dibenzylbutyrolactone lignan, (2R,3R)-5′-methoxyguayarol (1), was isolated from an EtOAc-soluble extract of the seeds of Hernandia ovigera using an in vitro activity-guided fractionation procedure based on the inhibition of cyclooxygenase-2. Also obtained were three known fatty acid derivatives, (S)-coriolic acid, (±)-12,13-epoxyoleic acid, and (±)-glycerol 1-monolinolate, and seven known lignans, epiashantin, dehydrodesoxypodophyllotoxin, dehydropodophyllotoxin, (-)-hernolactone, (-)-pinoresinol, (-)-syringaresinol, and (-)-yatein. The structure, including absolute stereochemistry, of compound 1 was determined using spectroscopic methods. All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, with (S)-coriolic acid and (±)-glycerol 1-monolinolate shown to have selective inhibitory activity with cyclooxygenase-2. | - |
dc.language | English | - |
dc.title | Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2 | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 70 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 893 | - |
dc.relation.lastpage | 896 | - |
dc.relation.journaltitle | Planta Medica | - |
dc.identifier.doi | 10.1055/s-2004-832612 | - |
dc.identifier.scopusid | 2-s2.0-7644237227 | - |
dc.author.google | Jang D.S. | - |
dc.author.google | Cuendet M. | - |
dc.author.google | Su B.-N. | - |
dc.author.google | Totura S. | - |
dc.author.google | Riswan S. | - |
dc.author.google | Fong H.H.S. | - |
dc.author.google | Pezzuto J.M. | - |
dc.author.google | Kinghorn A.D. | - |
dc.date.modifydate | 20180104081001 | - |