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Sesaminol glucosides protect β-amyloid peptide-induced cognitive deficits in mice

Title
Sesaminol glucosides protect β-amyloid peptide-induced cognitive deficits in mice
Authors
Um M.Y.Ahn J.Y.Kim S.Kim M.K.Ha T.Y.
Ewha Authors
김미경
SCOPUS Author ID
김미경scopusscopus
Issue Date
2009
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
vol. 32, no. 9, pp. 1516 - 1520
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This study was designed to investigate the effect of sesaminol glycosides (SG), one of the most abundant lignan glycosides in sesame (Sesamum indicum LINN.) seed, on cognitive deficits and oxidative stress induced by intracerebroventricular (i.c.v.) injection of β-amyloid protein (Aβ)25-35 in mice. Mice were fed diets containing 0%, 0.25%, or 0.5% of SG for six weeks. Dietary SG showed a protective effect against Aβ-induced learning and memory deficits in passive avoidance and the Morris water maze test. Aβ caused significant neuronal loss in the CA1 and CA3 regions of the hippocampus, but SG supplement showed decrease of the Aβ25-35 induced neuronal loss. The SG supplementation significantly decreased thiobarbituric acid reactive substance values and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in brain tissue. SG also reversed the activity of glutathione peroxidase (GPx), which is decreased by Aβ. These results suggest that SG protects against cognitive deficits induced by Aβ25-35, in part through its antioxidant activity. © 2009 Pharmaceutical Society of Japan.
DOI
10.1248/bpb.32.1516
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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