Bulletin of the Korean Chemical Society vol. 30, no. 7, pp. 1463 - 1469
Indexed
SCI; SCIE; SCOPUS; KCI
Document Type
Article
Abstract
Eleven novel oxiranyl and thiiranyl phenolic compounds were synthesized as potential antitumor agents using epichlorohydrin and epithiohydrin in the presence of K 2CO 3. Cytotoxicities were found in range of IC 50 values of 2.5-14.8 μM, which was partially attributed to topoisomerase II inhibition. Bis-thiiranyl anthraquinone analog, 19 showed more cytotoxicity against MDA-MB-231 (breast cancer cell) and PC3 (prostate cancer cell) after 24 and/or 48 h and more potent topoisomerase II inhibitory activity than etoposide.