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Design, synthesis, antitumor activity and mode of action of novel oxiranyl and thiiranyl phenol derivatives

Title
Design, synthesis, antitumor activity and mode of action of novel oxiranyl and thiiranyl phenol derivatives
Authors
Yang Z.Kang J.-A.Kim W.H.Park A.-Y.Kim H.S.Kim J.Kim J.-A.Gong P.Jeong L.S.Moon H.R.
Ewha Authors
정낙신
Issue Date
2009
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 30, no. 7, pp. 1463 - 1469
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Eleven novel oxiranyl and thiiranyl phenolic compounds were synthesized as potential antitumor agents using epichlorohydrin and epithiohydrin in the presence of K 2CO 3. Cytotoxicities were found in range of IC 50 values of 2.5-14.8 μM, which was partially attributed to topoisomerase II inhibition. Bis-thiiranyl anthraquinone analog, 19 showed more cytotoxicity against MDA-MB-231 (breast cancer cell) and PC3 (prostate cancer cell) after 24 and/or 48 h and more potent topoisomerase II inhibitory activity than etoposide.
DOI
10.5012/bkcs.2009.30.7.1463
Appears in Collections:
약학대학 > 약학과 > Journal papers
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