Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2016-08-28T11:08:02Z | - |
dc.date.available | 2016-08-28T11:08:02Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.other | OAK-13265 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229284 | - |
dc.description.abstract | Eleven novel oxiranyl and thiiranyl phenolic compounds were synthesized as potential antitumor agents using epichlorohydrin and epithiohydrin in the presence of K 2CO 3. Cytotoxicities were found in range of IC 50 values of 2.5-14.8 μM, which was partially attributed to topoisomerase II inhibition. Bis-thiiranyl anthraquinone analog, 19 showed more cytotoxicity against MDA-MB-231 (breast cancer cell) and PC3 (prostate cancer cell) after 24 and/or 48 h and more potent topoisomerase II inhibitory activity than etoposide. | - |
dc.language | English | - |
dc.title | Design, synthesis, antitumor activity and mode of action of novel oxiranyl and thiiranyl phenol derivatives | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1463 | - |
dc.relation.lastpage | 1469 | - |
dc.relation.journaltitle | Bulletin of the Korean Chemical Society | - |
dc.identifier.doi | 10.5012/bkcs.2009.30.7.1463 | - |
dc.identifier.wosid | WOS:000268554800009 | - |
dc.identifier.scopusid | 2-s2.0-69249168872 | - |
dc.author.google | Yang Z. | - |
dc.author.google | Kang J.-A. | - |
dc.author.google | Kim W.H. | - |
dc.author.google | Park A.-Y. | - |
dc.author.google | Kim H.S. | - |
dc.author.google | Kim J. | - |
dc.author.google | Kim J.-A. | - |
dc.author.google | Gong P. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Moon H.R. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20211210153610 | - |