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Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis

Title
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis
Authors
Phifer S.S.Lee D.Seo E.-K.Kim N.-C.Graf T.N.Kroll D.J.Navarro H.A.Izydore R.A.Jimenez F.Garcia R.Rose W.C.Fairchild C.R.Wild R.Soejarto D.D.Farnsworth N.R.Kinghorn A.D.Oberlies N.H.Wall M.E.Wani M.C.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2007
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 70, no. 6, pp. 954 - 961
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E-N (1-10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure - activity relationships are suggested. The most potent compounds in the in vitro assays (1 and 2) were evaluated in vivo versus the P388 (murine lymphocytic leukemia) model, and alvaradoin E (1) showed antileukemic activity (125% T/C) at a dose of 0.2 mg kg-1 per injection when administered intraperitoneally. © 2007 American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np070005a
Appears in Collections:
약학대학 > 약학과 > Journal papers
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