Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T11:08:39Z | - |
dc.date.available | 2016-08-28T11:08:39Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-12971 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229026 | - |
dc.description.abstract | Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E-N (1-10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure - activity relationships are suggested. The most potent compounds in the in vitro assays (1 and 2) were evaluated in vivo versus the P388 (murine lymphocytic leukemia) model, and alvaradoin E (1) showed antileukemic activity (125% T/C) at a dose of 0.2 mg kg-1 per injection when administered intraperitoneally. © 2007 American Chemical Society and American Society of Pharmacognosy. | * |
dc.language | English | * |
dc.title | Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 70 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 954 | * |
dc.relation.lastpage | 961 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/np070005a | * |
dc.identifier.scopusid | 2-s2.0-34447295642 | * |
dc.author.google | Phifer S.S. | * |
dc.author.google | Lee D. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Kim N.-C. | * |
dc.author.google | Graf T.N. | * |
dc.author.google | Kroll D.J. | * |
dc.author.google | Navarro H.A. | * |
dc.author.google | Izydore R.A. | * |
dc.author.google | Jimenez F. | * |
dc.author.google | Garcia R. | * |
dc.author.google | Rose W.C. | * |
dc.author.google | Fairchild C.R. | * |
dc.author.google | Wild R. | * |
dc.author.google | Soejarto D.D. | * |
dc.author.google | Farnsworth N.R. | * |
dc.author.google | Kinghorn A.D. | * |
dc.author.google | Oberlies N.H. | * |
dc.author.google | Wall M.E. | * |
dc.author.google | Wani M.C. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |