Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2016-08-28T10:08:36Z | - |
dc.date.available | 2016-08-28T10:08:36Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1021-335X | * |
dc.identifier.other | OAK-10493 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/224076 | - |
dc.description.abstract | Neuroblastoma is a solid tumor often diagnosed in childhood. While there have been intense efforts to develop a treatment for neuroblastoma, current therapies remain unsuccessful due to high rate of resistance and metastasis. Most cancers originate from a subset of self-renewing cells, primarily cancer stem cells (CSCs), which establish a tumor through continuous self-renewal and differentiation. The successful elimination of CSCs is an important goal in the development of effective strategies to achieve complete remission for cancers. Although β-carotene has been associated with several anticancer mechanisms, the efficacy of β-carotene against CSCs remains unclear. In the present study, β-carotene was shown to reduce cell growth and induce neuronal cell differentiation, concomitant with a marked increase in the phosphorylation of extracellular signal-regulated kinases (ERK) (p42/p44). More importantly, β-carotene inhibited self-renewal characteristics of CSCs and decreased expression of several stem cell markers. Levels of mRNA and protein of Drosophila delta-like 1 homolog (Drosophila) (DLK1) were downregulated following treatment with β-carotene. In addition, knockdown of DLK1 by siRNA enhanced the inhibitory effect of β-carotene on colony formation of neuroblastoma cells. β-carotene also potentiated the effect of cisplatin on the self-renewal characteristics of CSCs in neuroblastoma, revealing that β-carotene has the capacity to resensitize cells to cisplatin cytotoxicity by directly targeting CSCs. In conclusion, β-carotene was shown to strongly increase the anticancer efficacy against neuroblastoma cancer stem-like cells. Moreover, these results suggest that the targeting of CSCs is a novel mechanism of β-carotene. Thus, β-carotene is a potential chemotherapeutic reagent for this cancer. | * |
dc.language | English | * |
dc.title | Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1869 | * |
dc.relation.lastpage | 1877 | * |
dc.relation.journaltitle | Oncology Reports | * |
dc.identifier.doi | 10.3892/or.2013.2643 | * |
dc.identifier.wosid | WOS:000324539700044 | * |
dc.identifier.scopusid | 2-s2.0-84882658697 | * |
dc.author.google | Lee H.A. | * |
dc.author.google | Park S. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |