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Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

Title
Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
Authors
Hahn D.Won D.H.Mun B.Kim H.Han C.Wang W.Chun T.Park S.Yoon D.Choi H.Nam S.-J.Ekins M.Chin J.Kang H.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2013
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 23, no. 8, pp. 2336 - 2339
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23- hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23- hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM. © 2013 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2013.02.061
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자연과학대학 > 화학·나노과학전공 > Journal papers
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