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Synthesis and inhibition effects on 5-HT6 receptor of benzothiazole derivatives

Title
Synthesis and inhibition effects on 5-HT6 receptor of benzothiazole derivatives
Authors
Hayat F.Yoo E.Rhim H.Choo H.-Y.P.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2013
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 34, no. 2, pp. 495 - 499
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
A novel series of aryl sulfonylpiperazine derivatives (5-15) were synthesized as 5-HT6 ligands. In vitro assay was evaluated by measuring the 5-HT-induced Ca2+ increases using HeLa cell line expressing the cloned human 5-HT6 receptor, and the compound 13 showed potent 5-HT6 receptor antagonistic effect with IC50 value of 3.9 μM. Compound 13 also showed good selectivity on the 5-HT6 over 5-HT4 and 5-HT7 receptors.
DOI
10.5012/bkcs.2013.34.2.495
Appears in Collections:
약학대학 > 약학과 > Journal papers
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