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Drug-ceramic 2-dimensional nanoassemblies for drug delivery system in physiological condition

Title
Drug-ceramic 2-dimensional nanoassemblies for drug delivery system in physiological condition
Authors
Choi G.Kim S.Y.Oh J.-M.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2012
Journal Title
Journal of the American Ceramic Society
ISSN
0002-7820JCR Link
Citation
vol. 95, no. 9, pp. 2758 - 2765
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The anticancer drug methotrexate (MTX) was successfully incorporated into the layered ceramic nanoparticles of layered double hydroxides (LDHs). The prepared MTX-LDH two-dimensional nanoassemblies showed enhanced chemical and thermal stability of intercalated MTX molecules through the effective electrostatic interaction with ceramic LDH layers. And the surface charge of MTX-LDHs was determined to be highly positive whereas that of MTX is fairly negative. The anticancer effect of MTX-LDH compared with MTX was evaluated in the human osteosarcoma cell culture line SaOS-2, showing much faster drug efficacy with low concentration. The time-dependent cellular uptake of MTX determined by high performance liquid chromatography showed the much enhanced cellular drug concentration of MTX-LDH treated cancer cells than the MTX treated ones. The particle size of MTX-LDH nanoassemblies was estimated in various solutions such as saline, phosphate saline, and RPMI 1640 cell culture medium, showing that the hydrodynamic size maintains at ∼100 nm, regardless of the suspension media. The positive surface charge and ∼100 nm size of MTX-LDHs is considered to be the major factor in the high cellular uptake and enhanced drug efficacy. © 2012 The American Ceramic Society.
DOI
10.1111/j.1551-2916.2012.05219.x
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자연과학대학 > 화학·나노과학전공 > Journal papers
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