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dc.contributor.author최진호-
dc.date.accessioned2016-08-28T10:08:42Z-
dc.date.available2016-08-28T10:08:42Z-
dc.date.issued2012-
dc.identifier.issn0002-7820-
dc.identifier.otherOAK-9164-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/222971-
dc.description.abstractThe anticancer drug methotrexate (MTX) was successfully incorporated into the layered ceramic nanoparticles of layered double hydroxides (LDHs). The prepared MTX-LDH two-dimensional nanoassemblies showed enhanced chemical and thermal stability of intercalated MTX molecules through the effective electrostatic interaction with ceramic LDH layers. And the surface charge of MTX-LDHs was determined to be highly positive whereas that of MTX is fairly negative. The anticancer effect of MTX-LDH compared with MTX was evaluated in the human osteosarcoma cell culture line SaOS-2, showing much faster drug efficacy with low concentration. The time-dependent cellular uptake of MTX determined by high performance liquid chromatography showed the much enhanced cellular drug concentration of MTX-LDH treated cancer cells than the MTX treated ones. The particle size of MTX-LDH nanoassemblies was estimated in various solutions such as saline, phosphate saline, and RPMI 1640 cell culture medium, showing that the hydrodynamic size maintains at ∼100 nm, regardless of the suspension media. The positive surface charge and ∼100 nm size of MTX-LDHs is considered to be the major factor in the high cellular uptake and enhanced drug efficacy. © 2012 The American Ceramic Society.-
dc.languageEnglish-
dc.titleDrug-ceramic 2-dimensional nanoassemblies for drug delivery system in physiological condition-
dc.typeConference Paper-
dc.relation.issue9-
dc.relation.volume95-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2758-
dc.relation.lastpage2765-
dc.relation.journaltitleJournal of the American Ceramic Society-
dc.identifier.doi10.1111/j.1551-2916.2012.05219.x-
dc.identifier.wosidWOS:000308290400014-
dc.identifier.scopusid2-s2.0-84865725504-
dc.author.googleChoi G.-
dc.author.googleKim S.Y.-
dc.author.googleOh J.-M.-
dc.author.googleChoy J.-H.-
dc.contributor.scopusid최진호(8044393000)-
dc.date.modifydate20190301081000-
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