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Over-Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Dendritic Cells Negatively Regulates Cellular Responses to Bacterial Lipopolysaccharide
- Over-Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Dendritic Cells Negatively Regulates Cellular Responses to Bacterial Lipopolysaccharide
- Seul H.J.; Ahn Y.R.; Song H.M.; Ha Y.J.; Lee J.R.
- Ewha Authors
- SCOPUS Author ID
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- Journal Title
- Molecules and Cells
- Molecules and Cells vol. 34, no. 2, pp. 159 - 164
- SCI; SCIE; SCOPUS; KCI
- Document Type
- We studied the role of a RhoA-specific guanine nucleotide exchange factor (p190RhoGEF) in dendritic cells (DCs), using transgenic (TG) mice that over-express a full gene of p190RhoGEF under the control of an invariant chain promoter. TG mice lacked localization of activated DCs to the T cell zone in the spleen and had reduced serum levels of IL-6 in response to lipopolysaccharide (LPS) injection. DCs from these mice also showed reduced surface expression of CD86, CD40, and CD205, but not MHCII, as well as a reduced capability to uptake antigen. Moreover, chemokinedriven migration and secretion of IL-6, but not of IL-12, were impaired after LPS-stimulation of TG DCs. Collectively, these results suggest that over-expressing p190RhoGEF negatively regulates conventional DC function in response to bacterial LPS infection. © The Korean Society for Molecular and Cellular Biology. All rights reserved.
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