Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이종란 | - |
dc.date.accessioned | 2016-08-28T10:08:39Z | - |
dc.date.available | 2016-08-28T10:08:39Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | OAK-9125 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222940 | - |
dc.description.abstract | We studied the role of a RhoA-specific guanine nucleotide exchange factor (p190RhoGEF) in dendritic cells (DCs), using transgenic (TG) mice that over-express a full gene of p190RhoGEF under the control of an invariant chain promoter. TG mice lacked localization of activated DCs to the T cell zone in the spleen and had reduced serum levels of IL-6 in response to lipopolysaccharide (LPS) injection. DCs from these mice also showed reduced surface expression of CD86, CD40, and CD205, but not MHCII, as well as a reduced capability to uptake antigen. Moreover, chemokinedriven migration and secretion of IL-6, but not of IL-12, were impaired after LPS-stimulation of TG DCs. Collectively, these results suggest that over-expressing p190RhoGEF negatively regulates conventional DC function in response to bacterial LPS infection. © The Korean Society for Molecular and Cellular Biology. All rights reserved. | - |
dc.language | English | - |
dc.title | Over-Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Dendritic Cells Negatively Regulates Cellular Responses to Bacterial Lipopolysaccharide | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 34 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 159 | - |
dc.relation.lastpage | 164 | - |
dc.relation.journaltitle | Molecules and Cells | - |
dc.identifier.doi | 10.1007/s10059-012-0055-9 | - |
dc.identifier.wosid | WOS:000307767400007 | - |
dc.identifier.scopusid | 2-s2.0-84865320861 | - |
dc.author.google | Seul H.J. | - |
dc.author.google | Ahn Y.R. | - |
dc.author.google | Song H.M. | - |
dc.author.google | Ha Y.J. | - |
dc.author.google | Lee J.R. | - |
dc.contributor.scopusid | 이종란(37960967100) | - |
dc.date.modifydate | 20230411105011 | - |