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Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation

Title
Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
Authors
Jung I.-H.Lee Y.-H.Yoo J.-Y.Jeong S.-J.Sonn S.K.Park J.-G.Ryu K.H.Lee B.Y.Han H.Y.Lee S.Y.Kim D.-Y.Lee H.Oh G.T.
Ewha Authors
오구택손성근
SCOPUS Author ID
오구택scopus; 손성근scopus
Issue Date
2012
Journal Title
Experimental and Molecular Medicine
ISSN
1226-3613JCR Link
Citation
vol. 44, no. 5, pp. 311 - 318
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis. © 2012 by the Korean Society for Biochemistry and Molecular Biology.
DOI
10.3858/emm.2012.44.5.035
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자연과학대학 > 생명과학전공 > Journal papers
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