Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.contributor.author | 손성근 | * |
dc.date.accessioned | 2016-08-28T12:08:31Z | - |
dc.date.available | 2016-08-28T12:08:31Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1226-3613 | * |
dc.identifier.other | OAK-8878 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222729 | - |
dc.description.abstract | In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis. © 2012 by the Korean Society for Biochemistry and Molecular Biology. | * |
dc.language | English | * |
dc.title | Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 311 | * |
dc.relation.lastpage | 318 | * |
dc.relation.journaltitle | Experimental and Molecular Medicine | * |
dc.identifier.doi | 10.3858/emm.2012.44.5.035 | * |
dc.identifier.wosid | WOS:000304896600001 | * |
dc.identifier.scopusid | 2-s2.0-84861594528 | * |
dc.author.google | Jung I.-H. | * |
dc.author.google | Lee Y.-H. | * |
dc.author.google | Yoo J.-Y. | * |
dc.author.google | Jeong S.-J. | * |
dc.author.google | Sonn S.K. | * |
dc.author.google | Park J.-G. | * |
dc.author.google | Ryu K.H. | * |
dc.author.google | Lee B.Y. | * |
dc.author.google | Han H.Y. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Kim D.-Y. | * |
dc.author.google | Lee H. | * |
dc.author.google | Oh G.T. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 손성근(8628610900) | * |
dc.date.modifydate | 20240123094756 | * |