Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2016-08-28T12:08:29Z | - |
dc.date.available | 2016-08-28T12:08:29Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1743-7075 | * |
dc.identifier.other | OAK-8861 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222714 | - |
dc.description.abstract | Background: Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fat diet-fed mice, providing a model of NAFLD. Methods. Twenty-four mice were randomly divided into three groups (n = 8 in each group): normal fat diet (ND), high fat diet (HF), and high fat diet supplemented with 1% (w/w) BRE (HF +1% BRE). The experimental diets were fed for seven weeks. Results: A HF induced hepatic steatosis with significant increases in the serum levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (TC), and insulin. By contrast, supplementary BRE (10 g/kg of diet) included in the HF alleviated hepatic steatosis and significantly decreased serum TG and TC levels (p < 0.01 for both). Dietary BRE also increased expression of fatty acid metabolism-related genes, including carnitine palmitoyltransferase (CPT1A), acyl-CoA oxidase (ACO), cytochrome P450 (CYP4A10), and peroxisome proliferator activated receptor (PPAR)- (p < 0.05 for all). Conclusions: Dietary BRE supplementation improved serum lipid profiles and significantly enhanced mRNA expression levels of fatty acid metabolism-related genes, primarily via -oxidation and -oxidation in the liver. Taken together, these findings suggest that a BRE-supplemented diet could be useful in reducing the risks of hepatic steatosis and related disorders, including hyperlipidemia and hyperglycemia. © 2012 Jang et al; licensee BioMed Central Ltd. | * |
dc.language | English | * |
dc.title | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation | * |
dc.type | Article | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nutrition and Metabolism | * |
dc.identifier.doi | 10.1186/1743-7075-9-27 | * |
dc.identifier.wosid | WOS:000304763900001 | * |
dc.identifier.scopusid | 2-s2.0-84859091966 | * |
dc.author.google | Jang H.-H. | * |
dc.author.google | Park M.-Y. | * |
dc.author.google | Kim H.-W. | * |
dc.author.google | Lee Y.-M. | * |
dc.author.google | Hwang K.-A. | * |
dc.author.google | Park J.-H. | * |
dc.author.google | Park D.-S. | * |
dc.author.google | Kwon O. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123125010 | * |