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Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

Title
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
Authors
Thapa P.Karki R.Yun M.Kadayat T.M.Lee E.Kwon H.B.Na Y.Cho W.-J.Kim N.D.Jeong B.-S.Kwon Y.Lee E.-S.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2012
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 52, pp. 123 - 136
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. © 2012 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.ejmech.2012.03.010
Appears in Collections:
약학대학 > 약학과 > Journal papers
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