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Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
- Title
- Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
- Authors
- Thapa P.; Karki R.; Yun M.; Kadayat T.M.; Lee E.; Kwon H.B.; Na Y.; Cho W.-J.; Kim N.D.; Jeong B.-S.; Kwon Y.; Lee E.-S.
- Ewha Authors
- 권영주
- SCOPUS Author ID
- 권영주
- Issue Date
- 2012
- Journal Title
- European Journal of Medicinal Chemistry
- ISSN
- 0223-5234
- Citation
- European Journal of Medicinal Chemistry vol. 52, pp. 123 - 136
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. © 2012 Elsevier Masson SAS. All rights reserved.
- DOI
- 10.1016/j.ejmech.2012.03.010
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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