Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:26Z | - |
dc.date.available | 2016-08-28T12:08:26Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-8815 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222675 | - |
dc.description.abstract | We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. © 2012 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety | * |
dc.type | Article | * |
dc.relation.volume | 52 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 123 | * |
dc.relation.lastpage | 136 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2012.03.010 | * |
dc.identifier.wosid | WOS:000304291600012 | * |
dc.identifier.scopusid | 2-s2.0-84860343547 | * |
dc.author.google | Thapa P. | * |
dc.author.google | Karki R. | * |
dc.author.google | Yun M. | * |
dc.author.google | Kadayat T.M. | * |
dc.author.google | Lee E. | * |
dc.author.google | Kwon H.B. | * |
dc.author.google | Na Y. | * |
dc.author.google | Cho W.-J. | * |
dc.author.google | Kim N.D. | * |
dc.author.google | Jeong B.-S. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |