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Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity

Title
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity
Authors
Choi W.J.Chung H.-J.Chandra G.Alexander V.Zhao L.X.Lee H.W.Nayak A.Majik M.S.Kim H.O.Kim J.-H.Lee Y.B.Ahn C.H.Lee S.K.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2012
Journal Title
Journal of Medicinal Chemistry
ISSN
0022-2623JCR Link
Citation
vol. 55, no. 9, pp. 4521 - 4525
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor activity in a nude mouse tumor xenograft model implanted with A549 human lung cancer cells. However, its 2′-deoxycytidine derivative 5b did not show any antigrowth effects, indicating that 2′-hydroxyl group is essential for the biological activity. © 2012 American Chemical Society.
DOI
10.1021/jm3004009
Appears in Collections:
약학대학 > 약학과 > Journal papers
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