Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:21Z | - |
dc.date.available | 2016-08-28T12:08:21Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.other | OAK-8767 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222631 | - |
dc.description.abstract | On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor activity in a nude mouse tumor xenograft model implanted with A549 human lung cancer cells. However, its 2′-deoxycytidine derivative 5b did not show any antigrowth effects, indicating that 2′-hydroxyl group is essential for the biological activity. © 2012 American Chemical Society. | - |
dc.language | English | - |
dc.title | Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity | - |
dc.type | Article | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 55 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4521 | - |
dc.relation.lastpage | 4525 | - |
dc.relation.journaltitle | Journal of Medicinal Chemistry | - |
dc.identifier.doi | 10.1021/jm3004009 | - |
dc.identifier.wosid | WOS:000303785900039 | - |
dc.identifier.scopusid | 2-s2.0-84861028393 | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Chandra G. | - |
dc.author.google | Alexander V. | - |
dc.author.google | Zhao L.X. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Nayak A. | - |
dc.author.google | Majik M.S. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Kim J.-H. | - |
dc.author.google | Lee Y.B. | - |
dc.author.google | Ahn C.H. | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |