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Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation

Title
Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation
Authors
Ha Y.J.Jeong J.H.Park Y.Lee J.R.
Ewha Authors
이종란
SCOPUS Author ID
이종란scopus
Issue Date
2012
Journal Title
Experimental and Molecular Medicine
ISSN
1226-3613JCR Link
Citation
vol. 44, no. 2, pp. 138 - 148
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Previously, we demonstrated that the p190 Rho guanine nucleotide exchange factor (p190RhoGEF) was induced following CD40 stimulation of B cells. In this study, we examined whether p190RhoGEF and a downstream effector molecule RhoA are required for B cell differentiation. Expression of p190RhoGEF positively correlated with the expression of surface markers and transcriptional regulators that are characteristic of mature B cells with plasma cell (PC) phenotypes. Moreover, either the overexpression of p190RhoGEF or the expression of a constitutively active RhoA drove cellular differentiation toward PC phenotypes. B cell maturation was abrogated in cells that overexpressed p190RhoGEF and a dominant-negative form of RhoA simultaneously. CD40-mediated maturation events were also abrogated in cells that overexpressed either dominant-negative p190RhoGEF or RhoA. Together, these data provide evidence that p190RhoGEF signaling through RhoA in CD40-activated B cells drives the induction of the PC differentiation. © 2012 by the The Korean Society for Biochemistry and Molecular Biology.
DOI
10.3858/emm.2012.44.2.009
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자연과학대학 > 생명과학전공 > Journal papers
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