Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이종란 | - |
dc.date.accessioned | 2016-08-28T12:08:17Z | - |
dc.date.available | 2016-08-28T12:08:17Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | OAK-8706 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222585 | - |
dc.description.abstract | Previously, we demonstrated that the p190 Rho guanine nucleotide exchange factor (p190RhoGEF) was induced following CD40 stimulation of B cells. In this study, we examined whether p190RhoGEF and a downstream effector molecule RhoA are required for B cell differentiation. Expression of p190RhoGEF positively correlated with the expression of surface markers and transcriptional regulators that are characteristic of mature B cells with plasma cell (PC) phenotypes. Moreover, either the overexpression of p190RhoGEF or the expression of a constitutively active RhoA drove cellular differentiation toward PC phenotypes. B cell maturation was abrogated in cells that overexpressed p190RhoGEF and a dominant-negative form of RhoA simultaneously. CD40-mediated maturation events were also abrogated in cells that overexpressed either dominant-negative p190RhoGEF or RhoA. Together, these data provide evidence that p190RhoGEF signaling through RhoA in CD40-activated B cells drives the induction of the PC differentiation. © 2012 by the The Korean Society for Biochemistry and Molecular Biology. | - |
dc.language | English | - |
dc.title | Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 44 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 138 | - |
dc.relation.lastpage | 148 | - |
dc.relation.journaltitle | Experimental and Molecular Medicine | - |
dc.identifier.doi | 10.3858/emm.2012.44.2.009 | - |
dc.identifier.wosid | WOS:000303100700009 | - |
dc.identifier.scopusid | 2-s2.0-84863261176 | - |
dc.author.google | Ha Y.J. | - |
dc.author.google | Jeong J.H. | - |
dc.author.google | Park Y. | - |
dc.author.google | Lee J.R. | - |
dc.contributor.scopusid | 이종란(37960967100) | - |
dc.date.modifydate | 20230411105011 | - |