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Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain

Title
Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain
Authors
Lee E.Eom J.-E.Kim H.-L.Kang D.-H.Jun K.-Y.Jung D.S.Kwon Y.
Ewha Authors
권영주전규연
SCOPUS Author ID
권영주scopus
Issue Date
2012
Journal Title
European Journal of Pharmaceutical Sciences
ISSN
0928-0987JCR Link
Citation
vol. 46, no. 41276, pp. 17 - 25
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The key neuropathological features of Alzheimer's disease are abnormal deposition of Aβ plaques and insoluble Aβ peptides in extracellular brain and intracellular neurofibril tangles induced by abnormal tau hyperphosphorylation. μ-Calpain is one of the factors that bridge these Aβ- and hyperphosphorylated tau-mediated pathological pathways. Undecylenic acid (UDA), a naturally occurring unsaturated fatty acid, was discovered as a μ-calpain inhibitor by screening a chemical library using a substrate specific μ-calpain assay method. UDA inhibited Aβ oligomerization and Aβ fibrillation and reversed Aβ-induced neuronal cell death. In addition, UDA scavenged ROS and reversed the levels of proapoptotic proteins induced by ROS in SH-SY5Y cells. UDA inhibited μ-calpain activity with better potency than the known peptide-like μ-calpain inhibitor, MDL28170, in SH-SY5Y and HEK293T cells transfected with the catalytic subunit of μ-calpain. These results suggest that UDA is a novel non-peptide-like μ-calpain inhibitor with good cell permeability and potent neuroprotective effect. © 2012 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ejps.2012.01.015
Appears in Collections:
약학대학 > 약학과 > Journal papers
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