Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.contributor.author | 전규연 | * |
dc.date.accessioned | 2016-08-28T12:08:16Z | - |
dc.date.available | 2016-08-28T12:08:16Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0928-0987 | * |
dc.identifier.other | OAK-8699 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222578 | - |
dc.description.abstract | The key neuropathological features of Alzheimer's disease are abnormal deposition of Aβ plaques and insoluble Aβ peptides in extracellular brain and intracellular neurofibril tangles induced by abnormal tau hyperphosphorylation. μ-Calpain is one of the factors that bridge these Aβ- and hyperphosphorylated tau-mediated pathological pathways. Undecylenic acid (UDA), a naturally occurring unsaturated fatty acid, was discovered as a μ-calpain inhibitor by screening a chemical library using a substrate specific μ-calpain assay method. UDA inhibited Aβ oligomerization and Aβ fibrillation and reversed Aβ-induced neuronal cell death. In addition, UDA scavenged ROS and reversed the levels of proapoptotic proteins induced by ROS in SH-SY5Y cells. UDA inhibited μ-calpain activity with better potency than the known peptide-like μ-calpain inhibitor, MDL28170, in SH-SY5Y and HEK293T cells transfected with the catalytic subunit of μ-calpain. These results suggest that UDA is a novel non-peptide-like μ-calpain inhibitor with good cell permeability and potent neuroprotective effect. © 2012 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain | * |
dc.type | Article | * |
dc.relation.issue | 41276 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 17 | * |
dc.relation.lastpage | 25 | * |
dc.relation.journaltitle | European Journal of Pharmaceutical Sciences | * |
dc.identifier.doi | 10.1016/j.ejps.2012.01.015 | * |
dc.identifier.wosid | WOS:000303034500003 | * |
dc.identifier.scopusid | 2-s2.0-84862830140 | * |
dc.author.google | Lee E. | * |
dc.author.google | Eom J.-E. | * |
dc.author.google | Kim H.-L. | * |
dc.author.google | Kang D.-H. | * |
dc.author.google | Jun K.-Y. | * |
dc.author.google | Jung D.S. | * |
dc.author.google | Kwon Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.contributor.scopusid | 전규연(25632526500) | * |
dc.date.modifydate | 20240123101932 | * |