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dc.contributor.author권영주*
dc.contributor.author전규연*
dc.date.accessioned2016-08-28T12:08:16Z-
dc.date.available2016-08-28T12:08:16Z-
dc.date.issued2012*
dc.identifier.issn0928-0987*
dc.identifier.otherOAK-8699*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222578-
dc.description.abstractThe key neuropathological features of Alzheimer's disease are abnormal deposition of Aβ plaques and insoluble Aβ peptides in extracellular brain and intracellular neurofibril tangles induced by abnormal tau hyperphosphorylation. μ-Calpain is one of the factors that bridge these Aβ- and hyperphosphorylated tau-mediated pathological pathways. Undecylenic acid (UDA), a naturally occurring unsaturated fatty acid, was discovered as a μ-calpain inhibitor by screening a chemical library using a substrate specific μ-calpain assay method. UDA inhibited Aβ oligomerization and Aβ fibrillation and reversed Aβ-induced neuronal cell death. In addition, UDA scavenged ROS and reversed the levels of proapoptotic proteins induced by ROS in SH-SY5Y cells. UDA inhibited μ-calpain activity with better potency than the known peptide-like μ-calpain inhibitor, MDL28170, in SH-SY5Y and HEK293T cells transfected with the catalytic subunit of μ-calpain. These results suggest that UDA is a novel non-peptide-like μ-calpain inhibitor with good cell permeability and potent neuroprotective effect. © 2012 Elsevier B.V. All rights reserved.*
dc.languageEnglish*
dc.titleNeuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain*
dc.typeArticle*
dc.relation.issue41276*
dc.relation.volume46*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage17*
dc.relation.lastpage25*
dc.relation.journaltitleEuropean Journal of Pharmaceutical Sciences*
dc.identifier.doi10.1016/j.ejps.2012.01.015*
dc.identifier.wosidWOS:000303034500003*
dc.identifier.scopusid2-s2.0-84862830140*
dc.author.googleLee E.*
dc.author.googleEom J.-E.*
dc.author.googleKim H.-L.*
dc.author.googleKang D.-H.*
dc.author.googleJun K.-Y.*
dc.author.googleJung D.S.*
dc.author.googleKwon Y.*
dc.contributor.scopusid권영주(12446435600)*
dc.contributor.scopusid전규연(25632526500)*
dc.date.modifydate20240123101932*
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약학대학 > 약학과 > Journal papers
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