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A nanohybrid system for taste masking of sildenafil
- Title
- A nanohybrid system for taste masking of sildenafil
- Authors
- Lee J.-H.; Choi G.; Oh Y.-J.; Park J.W.; Choy Y.B.; Park M.C.; Yoon Y.J.; Lee H.J.; Chang H.C.; Choy J.-H.
- Ewha Authors
- 이화정; 윤여준; 최진호
- SCOPUS Author ID
- 이화정; 윤여준; 최진호
- Issue Date
- 2012
- Journal Title
- International Journal of Nanomedicine
- ISSN
- 1176-9114
- Citation
- International Journal of Nanomedicine vol. 7, pp. 1635 - 1649
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT), for taste masking of sildenafil (SDN). To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN-MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA). Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was successfully intercalated into the interlayer space of MMT. The AEA-coated SDN-MMT nanohybrid showed drug release was much suppressed at neutral pH (release rate, 4.70 ± 0.53%), suggesting a potential for drug taste masking at the buccal cavity. We also performed in vitro drug release experiments in a simulated gastric fluid (pH = 1.2) and compared the drug-release profiles of AEA-coated SDN-MMT and Viagra®, an approved dosage form of SDN. As a result, about 90% of SDN was released from the AEAcoated SDN-MMT during the first 2 hours while almost 100% of drug was released from Viagra®. However, an in vivo experiment showed that the AEA-coated SDN-MMT exhibited higher drug exposure than Viagra®. For the AEA-coated SDN-MMT, the area under the plasma concentration- time curve from 0 hours to infinity (AUC0-∞) and maximum concentration (Cmax) were 78.8 ± 2.32 μg · hour/mL and 12.4 ± 0.673 μg/mL, respectively, both of which were larger than those obtained with Viagra® (AUC0-∞ = 69.2 ± 3.19 μg · hour/mL; Cmax = 10.5 ± 0.641 μg/mL). Therefore, we concluded that the MMT-based nanohybrid is a promising delivery system for taste masking of SDN with possibly improved drug exposure. © 2012 Lee et al, publisher and licensee Dove Medical Press Ltd.
- DOI
- 10.2147/IJN.S28264
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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