Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이화정 | * |
dc.contributor.author | 윤여준 | * |
dc.contributor.author | 최진호 | * |
dc.date.accessioned | 2016-08-28T12:08:12Z | - |
dc.date.available | 2016-08-28T12:08:12Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1176-9114 | * |
dc.identifier.other | OAK-8663 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222543 | - |
dc.description.abstract | A nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT), for taste masking of sildenafil (SDN). To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN-MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA). Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was successfully intercalated into the interlayer space of MMT. The AEA-coated SDN-MMT nanohybrid showed drug release was much suppressed at neutral pH (release rate, 4.70 ± 0.53%), suggesting a potential for drug taste masking at the buccal cavity. We also performed in vitro drug release experiments in a simulated gastric fluid (pH = 1.2) and compared the drug-release profiles of AEA-coated SDN-MMT and Viagra®, an approved dosage form of SDN. As a result, about 90% of SDN was released from the AEAcoated SDN-MMT during the first 2 hours while almost 100% of drug was released from Viagra®. However, an in vivo experiment showed that the AEA-coated SDN-MMT exhibited higher drug exposure than Viagra®. For the AEA-coated SDN-MMT, the area under the plasma concentration- time curve from 0 hours to infinity (AUC0-∞) and maximum concentration (Cmax) were 78.8 ± 2.32 μg · hour/mL and 12.4 ± 0.673 μg/mL, respectively, both of which were larger than those obtained with Viagra® (AUC0-∞ = 69.2 ± 3.19 μg · hour/mL; Cmax = 10.5 ± 0.641 μg/mL). Therefore, we concluded that the MMT-based nanohybrid is a promising delivery system for taste masking of SDN with possibly improved drug exposure. © 2012 Lee et al, publisher and licensee Dove Medical Press Ltd. | * |
dc.language | English | * |
dc.title | A nanohybrid system for taste masking of sildenafil | * |
dc.type | Article | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1635 | * |
dc.relation.lastpage | 1649 | * |
dc.relation.journaltitle | International Journal of Nanomedicine | * |
dc.identifier.doi | 10.2147/IJN.S28264 | * |
dc.identifier.wosid | WOS:000302731300001 | * |
dc.identifier.scopusid | 2-s2.0-84866745265 | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Choi G. | * |
dc.author.google | Oh Y.-J. | * |
dc.author.google | Park J.W. | * |
dc.author.google | Choy Y.B. | * |
dc.author.google | Park M.C. | * |
dc.author.google | Yoon Y.J. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Chang H.C. | * |
dc.author.google | Choy J.-H. | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.contributor.scopusid | 윤여준(7402126465) | * |
dc.contributor.scopusid | 최진호(8044393000) | * |
dc.date.modifydate | 20240118154655 | * |