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DeSUMOylating isopeptidase: A second class of SUMO protease
- DeSUMOylating isopeptidase: A second class of SUMO protease
- Shin E.J.; Shin H.M.; Nam E.; Kim W.S.; Kim J.-H.; Oh B.-H.; Yun Y.
- Ewha Authors
- SCOPUS Author ID
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- Journal Title
- EMBO Reports
- vol. 13, no. 4, pp. 339 - 346
- SCI; SCIE; SCOPUS
- The modification of proteins by small ubiquitin-like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases, collectively known as deSUMOylases. Only one family of SUMO-specific proteases has been described so far: the sentrin-specific proteases (SENP). Here, we identify and characterize a new deSUMOylase, which we have named DeSI-1 (DeSumoylating Isopeptidase 1). We describe BZEL-a new transcriptional repressor-as substrate of DeSI-1. DeSI-1 catalyses the deSUMOylation, but not the deubiquitination, of BZEL. Furthermore, the SENP substrates PML and δNp63 are not deSUMOylated by DeSI-1, suggesting that SENP and DeSI enzymes recognize different sets of substrates. Together, these data identify a second class of SUMO proteases. © 2012 European Molecular Biology Organization.
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