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DeSUMOylating isopeptidase: A second class of SUMO protease

Title
DeSUMOylating isopeptidase: A second class of SUMO protease
Authors
Shin E.J.Shin H.M.Nam E.Kim W.S.Kim J.-H.Oh B.-H.Yun Y.
Ewha Authors
윤영대
SCOPUS Author ID
윤영대scopus
Issue Date
2012
Journal Title
EMBO Reports
ISSN
1469-221XJCR Link
Citation
vol. 13, no. 4, pp. 339 - 346
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The modification of proteins by small ubiquitin-like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases, collectively known as deSUMOylases. Only one family of SUMO-specific proteases has been described so far: the sentrin-specific proteases (SENP). Here, we identify and characterize a new deSUMOylase, which we have named DeSI-1 (DeSumoylating Isopeptidase 1). We describe BZEL-a new transcriptional repressor-as substrate of DeSI-1. DeSI-1 catalyses the deSUMOylation, but not the deubiquitination, of BZEL. Furthermore, the SENP substrates PML and δNp63 are not deSUMOylated by DeSI-1, suggesting that SENP and DeSI enzymes recognize different sets of substrates. Together, these data identify a second class of SUMO proteases. © 2012 European Molecular Biology Organization.
DOI
10.1038/embor.2012.3
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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