Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2016-08-28T12:08:12Z | - |
dc.date.available | 2016-08-28T12:08:12Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.other | OAK-8654 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222534 | - |
dc.description.abstract | The modification of proteins by small ubiquitin-like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases, collectively known as deSUMOylases. Only one family of SUMO-specific proteases has been described so far: the sentrin-specific proteases (SENP). Here, we identify and characterize a new deSUMOylase, which we have named DeSI-1 (DeSumoylating Isopeptidase 1). We describe BZEL-a new transcriptional repressor-as substrate of DeSI-1. DeSI-1 catalyses the deSUMOylation, but not the deubiquitination, of BZEL. Furthermore, the SENP substrates PML and δNp63 are not deSUMOylated by DeSI-1, suggesting that SENP and DeSI enzymes recognize different sets of substrates. Together, these data identify a second class of SUMO proteases. © 2012 European Molecular Biology Organization. | - |
dc.language | English | - |
dc.title | DeSUMOylating isopeptidase: A second class of SUMO protease | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 339 | - |
dc.relation.lastpage | 346 | - |
dc.relation.journaltitle | EMBO Reports | - |
dc.identifier.doi | 10.1038/embor.2012.3 | - |
dc.identifier.wosid | WOS:000302562500017 | - |
dc.identifier.scopusid | 2-s2.0-84862798314 | - |
dc.author.google | Shin E.J. | - |
dc.author.google | Shin H.M. | - |
dc.author.google | Nam E. | - |
dc.author.google | Kim W.S. | - |
dc.author.google | Kim J.-H. | - |
dc.author.google | Oh B.-H. | - |
dc.author.google | Yun Y. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20200901081003 | - |