Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김미경 | * |
dc.date.accessioned | 2016-08-28T12:08:11Z | - |
dc.date.available | 2016-08-28T12:08:11Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0364-3190 | * |
dc.identifier.other | OAK-8645 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222525 | - |
dc.description.abstract | We have investigated the neuroprotective effect of sesaminol glucosides (SG) in SK-N-SH cells. SG prevented apoptotic cell death induced by Aβ25-35. In parallel, SK-N-SH cells exposed to Aβ25-35 underwent oxidative stress as shown by the elevated level of intracellular ROS, lipid peroxidation, and 8-hydroxy-2′- deoxyguanosine (8-OHdG) formation, which were effectively suppressed by SG treatment. Furthermore, SG reversed the activities of catalase and glutathione peroxidase, and restored intracellular GSH levels in Aβ25-35 challenged SK-N-SH cells. In addition, SG inhibited not only Aβ25-35-induced apop- totic features including cleavage of poly(ADP-ribose) polymerase, activation of caspase-3, and activation of cas- pase-9, but also elevated Bax/Bcl-2 ratio in SK-N-SH cells treated with Aβ25-35. It was also observed that Aβ25-35 stimulated the phosphorylation of mitogen-activated protein kinases (MAPKs), including extracellular protein regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAP kinase. SG inhibited phosphorylation of the JNK, ERK and p38 MAP kinase. These results suggest that SG has a protective effect against Aβ25-35-induced neuronal apoptosis, possibly through scavenging oxidative stress and regulating MAPKs signaling pathways. © Springer Science+Business Media, LLC 2011. | * |
dc.language | English | * |
dc.title | Sesaminol glucosides protect β-amyloid induced apoptotic cell death by regulating redox system in SK-N-SH cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 689 | * |
dc.relation.lastpage | 699 | * |
dc.relation.journaltitle | Neurochemical Research | * |
dc.identifier.doi | 10.1007/s11064-011-0658-0 | * |
dc.identifier.wosid | WOS:000302404600003 | * |
dc.identifier.scopusid | 2-s2.0-84862880013 | * |
dc.author.google | Um M.Y. | * |
dc.author.google | Ahn J.Y. | * |
dc.author.google | Kim M.K. | * |
dc.author.google | Ha T.Y. | * |
dc.contributor.scopusid | 김미경(56372953900;58636726700) | * |
dc.date.modifydate | 20240415130440 | * |