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Combined effects of 60Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells
- Combined effects of 60Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells
- Lee H.-J.; Jin Y.B.; Lee J.S.; Choi J.-I.; Lee J.-W.; Myung S.H.; Lee Y.-S.
- Ewha Authors
- SCOPUS Author ID
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- Journal Title
- vol. 33, no. 3, pp. 207 - 214
- SCI; SCIE; SCOPUS
- Epidemiological studies have suggested that extremely low-frequency magnetic fields (ELF-MF) are associated with an increased incidence of cancer. Studies using in vitro systems have reported mixed results for the effects of ELF-MF alone, and the World Health Organization (WHO) Research Agenda published in 2007 suggested that high priority research should include an evaluation of the co-carcinogenic effects of ELF-MF exposure using in vitro models. Here, the carcinogenic potential of ELF-MF exposure alone and in combination with various stress factors was investigated in NIH3T3 mouse fibroblasts using an in vitro cellular transformation assay. NIH3T3 cells were exposed to a 60Hz ELF-MF (1mT) alone or in combination with ionizing radiation (IR), hydrogen peroxide (H 2O 2), or c-Myc overexpression, and the resulting number of anchorage-independent colonies was counted. A 4h exposure of NIH3T3 cells to ELF-MF alone produced no cell transformation. Moreover, ELF exposure did not influence the transformation activity of IR, H 2O 2, or activated c-Myc in our in vitro assay system, suggesting that 1mT ELF-MF did not affect any additive or synergistic transformation activities in combination with stress factors such as IR, H 2O 2, or activated c-Myc in NIH3T3 cells. © 2011 Wiley Periodicals, Inc.
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