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Association between ESR1 rs1884051 polymorphism and dietary total energy and plant protein intake on obesity in Korean men

Title
Association between ESR1 rs1884051 polymorphism and dietary total energy and plant protein intake on obesity in Korean men
Authors
Doo M.Kim Y.
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2011
Journal Title
Nutrition Research and Practice
ISSN
1976-1457JCR Link
Citation
vol. 5, no. 6, pp. 527 - 532
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
ESR1 has been listed in the Human Obesity Gene Map as candidate gene associated with obesity. Thus, in this study, we investigated the effect of the ESR1 rs1884051 polymorphism on obesity-related variables, together with their modulations by dietary intake in Korean men. The obesity-related variables and dietary intake of 3,039 Korean men aged 40-59 years from KoGES database were analyzed. Body weight (P = 0.007), BMI (P = 0.003), waist-hip ratio (= 0.011), fat body mass (P = 0.010), and body fat percentage (P = 0.040) were significantly lower in subjects with the minor T allele of ESR1 rs1884051 than in subjects carrying the C allele. Moreover, the rs1884051 T allele was associated with a decreased risk of obesity prevalence (P = 0.040). Among the subjects whose total energy intake was below the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.003) when compared with subjects carrying the C allele. In addition, among subjects whose plant protein intake was above the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.044) compared with subjects carrying the C allele. Our findings demonstrate that there is a significant association between the ESR1 rs1884051 variant and obesity-related variables and this association can be potentially modified by dietary energy and plant protein intake. © 2011 The Korean Nutrition Society and the Korean Society of Community Nutrition.
DOI
10.4162/nrp.2011.5.6.527
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신산업융합대학 > 식품영양학과 > Journal papers
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