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Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8- diones and furo[2,3-f]quinazolin-5-ols

Title
Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8- diones and furo[2,3-f]quinazolin-5-ols
Authors
Ryu C.-K.Kim Y.H.Im H.A.Kim J.Y.Yoon J.H.Kim A.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2012
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 22, no. 1, pp. 500 - 503
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
6,7-Bis(arylthio)-quinazoline-5,8-dione and furo[2,3-f]quinazolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many of furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones showed good antifungal activity. The compounds 4a and 4e completely inhibited the growth of all against Candida and Aspergillus species tested at the MIC level of 12.5 μg/mL. The results suggest that furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones would be promising antifungal agents. © 2011 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2011.10.099
Appears in Collections:
약학대학 > 약학과 > Journal papers
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