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Mulberry leaf water extract ameliorates insulin sensitivity in high fat or high sucrose diet induced overweight rats

Title
Mulberry leaf water extract ameliorates insulin sensitivity in high fat or high sucrose diet induced overweight rats
Authors
Kim J.Y.Choi B.G.Jung M.J.Wee J.-H.Chung K.H.Kwon O.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2011
Journal Title
Journal of the Korean Society for Applied Biological Chemistry
ISSN
1738-2203JCR Link
Citation
vol. 54, no. 4, pp. 612 - 618
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Effects of aqueous mulberry leaf extract (Morus alba L.) on glucose and lipid metabolisms in highfat and high-sucrose diet-induced overweight animal models were examined. Supplementation of mulberry leaf extract (MLE) resulted in body weight changes in both high-fat- and high-sucroseinduced overweight rats. Plasma insulin and Homeostasis model assessment-insulin resistance also significantly decreased by MLE treatment (p<0.05). In addition, plasma free fatty acid level was also decreased by MLE supplementation in high-fat diet-induced overweight rat (p<0.05). MLE supplementation significantly (p<0.05) increased the expression of insulin receptor genes at the transcriptional level. MLE supplementation decreased plasma insulin concentrations increased by high-fat or high-sucrose diets and improved insulin sensitivity by increasing the expression level of insulin receptor in muscle and adipose tissue.
DOI
10.3839/jksabc.2011.092
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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