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Nonhalogenated solvent-based solvent evaporation process useful in preparation of PLGA microspheres

Title
Nonhalogenated solvent-based solvent evaporation process useful in preparation of PLGA microspheres
Authors
Jang J.Sah H.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2011
Journal Title
Journal of Microencapsulation
ISSN
0265-2048JCR Link
Citation
vol. 28, no. 6, pp. 490 - 498
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to develop an isopropyl formate-based evaporation process useful in producing poly-D,L-lactide-co-glycolide microspheres. Surprisingly, the evaporating tendency of isopropyl formate was comparable to that of methylene chloride and far better than that of ethyl acetate. After optimization of the isopropyl formate-based process, progesterone was encapsulated into microspheres. Under our conditions, its encapsulation efficiency ranged from 75.1% to 92.6%. Even though all microspheres took spherical geometry, their external and internal morphologies were greatly influenced by progesterone payloads. A GC analysis demonstrated that residual isopropyl formate in various microspheres was 1.8% to 4.0%. Interestingly, progesterone underwent polymorphic transition during the microencapsulation process the β form was present in microspheres with lower progesterone payloads, whereas the α form predominated over the β one at higher progesterone loads. In terms of human safety and environmental toxicity, isopropyl formate might have an edge over halogenated organic solvents for solvent evaporation. © 2011 Informa UK Ltd. All rights reserved.
DOI
10.3109/02652048.2011.586066
Appears in Collections:
약학대학 > 약학과 > Journal papers
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