Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 사홍기 | - |
dc.date.accessioned | 2016-08-28T12:08:06Z | - |
dc.date.available | 2016-08-28T12:08:06Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0265-2048 | - |
dc.identifier.other | OAK-7859 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221861 | - |
dc.description.abstract | The objective of this study was to develop an isopropyl formate-based evaporation process useful in producing poly-D,L-lactide-co-glycolide microspheres. Surprisingly, the evaporating tendency of isopropyl formate was comparable to that of methylene chloride and far better than that of ethyl acetate. After optimization of the isopropyl formate-based process, progesterone was encapsulated into microspheres. Under our conditions, its encapsulation efficiency ranged from 75.1% to 92.6%. Even though all microspheres took spherical geometry, their external and internal morphologies were greatly influenced by progesterone payloads. A GC analysis demonstrated that residual isopropyl formate in various microspheres was 1.8% to 4.0%. Interestingly, progesterone underwent polymorphic transition during the microencapsulation process the β form was present in microspheres with lower progesterone payloads, whereas the α form predominated over the β one at higher progesterone loads. In terms of human safety and environmental toxicity, isopropyl formate might have an edge over halogenated organic solvents for solvent evaporation. © 2011 Informa UK Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Nonhalogenated solvent-based solvent evaporation process useful in preparation of PLGA microspheres | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 490 | - |
dc.relation.lastpage | 498 | - |
dc.relation.journaltitle | Journal of Microencapsulation | - |
dc.identifier.doi | 10.3109/02652048.2011.586066 | - |
dc.identifier.wosid | WOS:000293744700004 | - |
dc.identifier.scopusid | 2-s2.0-80051709046 | - |
dc.author.google | Jang J. | - |
dc.author.google | Sah H. | - |
dc.contributor.scopusid | 사홍기(56127728100) | - |
dc.date.modifydate | 20190901081003 | - |